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Advances in Melatonin Research – A Review
Review
Manuscript ID: CoAS_SP1_14
Advances in Melatonin Research – A Review
A. R. Jumnake*, V. R. Patodkar, N. E. Gavali, V. M. Sardar and P. V. Mehere
Abstract
The chemical known as melatonin, N-acetyl-5-methoxytryptamine, is widely dispersed and very versatile in its functional aspects. The processes involving the retina and biological clock that regulate the pineal gland's circadian melatonin production are quickly being discovered, and the mechanisms governing its synthesis within the gland have been thoroughly studied. According to the research, melatonin, both endogenous and exogenous, plays a significant role in promoting physiological and molecular adaptations in domestic animals and wildlife. Seasonally polyestrous animals have been the subject of substantial melatonin research. Herds of animals housed in photoperiodic aberrations have their circannual cycles corrected by supplementation procedures. One of its defining characteristics is the range of techniques melatonin uses to alter cell physiology and molecular biology. However, the antioxidant and immunostimulatory properties of melatonin may be able to mitigate these effects. During their production cycle, livestock undergo several metabolic and physiological adaptation processes that may impair their immune system and result in chronic sickness, weight loss, or decreased productivity. Melatonin has an impact on the heart and blood vessels. It can vasodilate or vasoconstrictor numerous systemic arteries, depending on the kind and location of its receptors. This modulates the animal's total nutrient partitioning through vascular resistance. The physiological, cellular, and molecular impacts of melatonin on the well-being and illnesses of domesticated food animals are the main topics of this review, along with recent developments in the subject.
Keywords
Antioxidant; circadian rhythms; reproductive physiology; functional element; immune function
References
Abdelnaby, E.A.; El-Maaty, A.M.A. Melatonin and CIDR improved the follicular and luteal hemodynamics, uterine and ovarian arteries vascular perfusion, ovarian hormones and nitric oxide in cyclic cows. Reprod. Domest. Anim. 2021, 56, 498–510.
Abdelrasoul, M., El‐Fattah, A. A., Kotry, G., Ramadan, O., Essawy, M., Kamaldin, J., & Kandil, S. (2022). Regeneration of critical‐sized grade II furcation using a novel injectable melatonin‐loaded scaffold. Oral Diseases.
Abulaiti, A., Nawaz, M., Naseer, Z., Ahmed, Z., Liu, W., Abdelrahman, M., & Wang, S. (2023).
Administration of melatonin before the modified synchronization protocol improves the productive and reproductive efficiency of Chinese crossbred buffaloes in the low breeding season. Frontiers in Veterinary Science, 10, 1118604.
Afeche SC, do Amaral FG, Villela DCM, Abrahão MV, Peres R, Cipolla-Neto J. Melatonin and the Pineal Gland. In: Romano E, De Luca S, editors. New Research on Neurosecretory Systems. New York: Nova Biomedical Books; 2008. p 151-77
Afeche, SC, Amaral, FGd, Villela, DCM, Abrahão, MV, Peres, R, Melatonin, Cipolla-Neto J., et al. New research on neurosecretory systems. Hauppauge: Nova Science Publishers. (2008) 21 151– 177.
Ahmad, S. B., Ali, A., Bilal, M., Rashid, S. M., Wani, A. B., Bhat, R. R., & Rehman, M. U. (2023). Melatonin and health: Insights of melatonin action, biological functions, and associated disorders. Cellular and Molecular Neurobiology, 1-22.
Al-Hamedawi, TM, and Hatif, SA. Effect of melatonin and in combination with CIDR on reproductive performance in anestrus lactating Iraqi buffaloes (Bubalus bubalis). Iraqi J Vet Med. (2020) 44:99–102. doi 10.30539/IJVM.V44I2.981
Abdelrasoul, M., El‐Fattah, A. A., Kotry, G., Ramadan, O., Essawy, M., Kamaldin, J., & Kandil, S. (2022). Regeneration of critical‐sized grade II furcation using a novel injectable melatonin‐loaded scaffold. Oral Diseases.
Abulaiti, A., Nawaz, M., Naseer, Z., Ahmed, Z., Liu, W., Abdelrahman, M., & Wang, S. (2023).
Administration of melatonin before the modified synchronization protocol improves the productive and reproductive efficiency of Chinese crossbred buffaloes in the low breeding season. Frontiers in Veterinary Science, 10, 1118604.
Afeche SC, do Amaral FG, Villela DCM, Abrahão MV, Peres R, Cipolla-Neto J. Melatonin and the Pineal Gland. In: Romano E, De Luca S, editors. New Research on Neurosecretory Systems. New York: Nova Biomedical Books; 2008. p 151-77
Afeche, SC, Amaral, FGd, Villela, DCM, Abrahão, MV, Peres, R, Melatonin, Cipolla-Neto J., et al. New research on neurosecretory systems. Hauppauge: Nova Science Publishers. (2008) 21 151– 177.
Ahmad, S. B., Ali, A., Bilal, M., Rashid, S. M., Wani, A. B., Bhat, R. R., & Rehman, M. U. (2023). Melatonin and health: Insights of melatonin action, biological functions, and associated disorders. Cellular and Molecular Neurobiology, 1-22.
Al-Hamedawi, TM, and Hatif, SA. Effect of melatonin and in combination with CIDR on reproductive performance in anestrus lactating Iraqi buffaloes (Bubalus bubalis). Iraqi J Vet Med. (2020) 44:99–102. doi 10.30539/IJVM.V44I2.981
AL-Shammary, S. M., & Al-Yasiri, E. A. (2023). Effect of Melatonin Implants on Sexual Behavior and Testosterone in Awassi Rams.
AL-SHAMMARY, Salah M.; AL-TIMIMI, Ihsan H.; AL-ANI, Ahmad A. Comparative study of Equine Chorionic Gonadotropine and Licorice Extract (Glycyrrhiza Glabra) on some Reproductive Traits in Awassi Ram Lambs. The Iraqi Journal of Veterinary Medicine, 2013, 37.2: 269-274.
Amaral, F. G. D., Andrade-Silva, J., Kuwabara, W. M., & Cipolla-Neto, J. (2019). New insights into the function of melatonin and its role in metabolic disturbances. Expert review of endocrinology & metabolism, 14(4), 293-300.
Anwar MM, Meki AR & Rahma HH 2001 Inhibitory effects of melatonin on vascular reactivity: possible role of vasoactive mediators. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 130 357–367 (doi:10.1016/s1532-0456(01)00261-7).
Armstrong SM. Melatonin and circadian control in mammals. Experientia. (1989) 45:932–8. doi: 10.1007/BF01953050
Arnao, M.; Hernández-Ruiz, J. Melatonin and Reactive Oxygen and Nitrogen Species: A Model for the Plant Redox Network. Melatonin Res. 2019, 2, 152–168.
Arnao, M.B.; Hernández-Ruiz, J. Melatonin: Synthesis from Tryptophan and Its Role in Higher Plants. In Amino Acids in Higher Plants; D’ Mello, J., Ed.; CAB Intern: Boston, MA, USA, 2015; pp. 390– 435. ISBN 978-1-78064-263-5.
Assani, B. V. M., Ayssiwede, S. B., & Kinnou, M. S. Evaluation of the Effects of Melatonin Implants on Testicular and Spermatic Parameters of Rams Raised in Station in the Niayes Zone in Senegal.
Attachaipanich, T., Chattipakorn, S. C., & Chattipakorn, N. (2023). Potential Roles of Melatonin in Doxorubicin-Induced Cardiotoxicity: From Cellular Mechanisms to Clinical Application. Pharmaceutics, 15(3), 785.
Augas J-P., Boyer M., Favre Bonvin J., Garraud E., Kuppel B., Melin N., Sagot L., Moulinard D., 2010. Reproduction: The main rules to produce a maximum of lambs - Reproduction: Les grandes règles pour produire un maximum d’agneaux. Bellac Ovin, CELMAR, CEPV, INSEM OVINE, CCBE, CIIRPO/Institut de l 'élevage. INRA Paris.
Bartsch, C., & Bartsch, H. (1999). Melatonin in cancer patients and tumor-bearing animals. Tryptophan, serotonin, and melatonin: Basic aspects and applications, 247-264.
Biancatelli, RMLC, Berrill, M, Mohammed, YH, and Marik, PE. Melatonin for the treatment of sepsis: the scientific rationale. J Thoracic Dis. (2020) 12:S54, S65. doi: 10.21037/jtd.2019.12.85
Bubenik, G. A., & Pang, S. F. (1997). Melatonin levels in the gastrointestinal tissues of fish, amphibians, and a reptile. General and Comparative Endocrinology, 106(3), 415-419.
Canto, F.; González, E.; Abecia, J.A. Effects of Implanting Exogenous Melatonin 40 Days before Lambing on Milk and Colostrum Quality. Animals 2022, 12, 1257.
Cardinali, D. P., Delagrange, P., Dubocovich, M. L., Jockers, R., Krause, D. N., Markus, R. P., ..... &
Zlotos, D. P. (2023). Melatonin receptors in GtoPdb v. 2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023(1).
Chemineau, P.; Normant, E.; Ravault, J.P.; Thimonier, J. Induction and persistence of pituitary and ovarian activity in the out-of-season lactating dairy goat after a treatment combining a skeleton photoperiod, melatonin, and the male effect. J. Reprod. Fertil. 1986, 78, 497–504
AL-SHAMMARY, Salah M.; AL-TIMIMI, Ihsan H.; AL-ANI, Ahmad A. Comparative study of Equine Chorionic Gonadotropine and Licorice Extract (Glycyrrhiza Glabra) on some Reproductive Traits in Awassi Ram Lambs. The Iraqi Journal of Veterinary Medicine, 2013, 37.2: 269-274.
Amaral, F. G. D., Andrade-Silva, J., Kuwabara, W. M., & Cipolla-Neto, J. (2019). New insights into the function of melatonin and its role in metabolic disturbances. Expert review of endocrinology & metabolism, 14(4), 293-300.
Anwar MM, Meki AR & Rahma HH 2001 Inhibitory effects of melatonin on vascular reactivity: possible role of vasoactive mediators. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 130 357–367 (doi:10.1016/s1532-0456(01)00261-7).
Armstrong SM. Melatonin and circadian control in mammals. Experientia. (1989) 45:932–8. doi: 10.1007/BF01953050
Arnao, M.; Hernández-Ruiz, J. Melatonin and Reactive Oxygen and Nitrogen Species: A Model for the Plant Redox Network. Melatonin Res. 2019, 2, 152–168.
Arnao, M.B.; Hernández-Ruiz, J. Melatonin: Synthesis from Tryptophan and Its Role in Higher Plants. In Amino Acids in Higher Plants; D’ Mello, J., Ed.; CAB Intern: Boston, MA, USA, 2015; pp. 390– 435. ISBN 978-1-78064-263-5.
Assani, B. V. M., Ayssiwede, S. B., & Kinnou, M. S. Evaluation of the Effects of Melatonin Implants on Testicular and Spermatic Parameters of Rams Raised in Station in the Niayes Zone in Senegal.
Attachaipanich, T., Chattipakorn, S. C., & Chattipakorn, N. (2023). Potential Roles of Melatonin in Doxorubicin-Induced Cardiotoxicity: From Cellular Mechanisms to Clinical Application. Pharmaceutics, 15(3), 785.
Augas J-P., Boyer M., Favre Bonvin J., Garraud E., Kuppel B., Melin N., Sagot L., Moulinard D., 2010. Reproduction: The main rules to produce a maximum of lambs - Reproduction: Les grandes règles pour produire un maximum d’agneaux. Bellac Ovin, CELMAR, CEPV, INSEM OVINE, CCBE, CIIRPO/Institut de l 'élevage. INRA Paris.
Bartsch, C., & Bartsch, H. (1999). Melatonin in cancer patients and tumor-bearing animals. Tryptophan, serotonin, and melatonin: Basic aspects and applications, 247-264.
Biancatelli, RMLC, Berrill, M, Mohammed, YH, and Marik, PE. Melatonin for the treatment of sepsis: the scientific rationale. J Thoracic Dis. (2020) 12:S54, S65. doi: 10.21037/jtd.2019.12.85
Bubenik, G. A., & Pang, S. F. (1997). Melatonin levels in the gastrointestinal tissues of fish, amphibians, and a reptile. General and Comparative Endocrinology, 106(3), 415-419.
Canto, F.; González, E.; Abecia, J.A. Effects of Implanting Exogenous Melatonin 40 Days before Lambing on Milk and Colostrum Quality. Animals 2022, 12, 1257.
Cardinali, D. P., Delagrange, P., Dubocovich, M. L., Jockers, R., Krause, D. N., Markus, R. P., ..... &
Zlotos, D. P. (2023). Melatonin receptors in GtoPdb v. 2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023(1).
Chemineau, P.; Normant, E.; Ravault, J.P.; Thimonier, J. Induction and persistence of pituitary and ovarian activity in the out-of-season lactating dairy goat after a treatment combining a skeleton photoperiod, melatonin, and the male effect. J. Reprod. Fertil. 1986, 78, 497–504
CHEMINEAU, Philippe, et al. Seasonality of reproduction in mammals: intimate regulatory mechanisms and practical implications. Reproduction in Domestic Animals, 2008, 43: 40-47.
Cipolla-Neto, J., & Amaral, F. G. D. (2018). Melatonin as a hormone: new physiological and clinical insights. Endocrine Reviews, 39(6), 990-1028.
Coelho, L. A., Silva, L. A., Reway, A. P., Buonfiglio, D. D. C., Andrade-Silva, J., Gomes, P. R. L., & Cipolla-Neto, J. (2023). Seasonal Variation of Melatonin Concentration and mRNA Expression of Melatonin-Related Genes in Developing Ovarian Follicles of Mares Kept under Natural Photoperiods in the Southern Hemisphere. Animals, 13(6), 1063.
Colas G., 1976. Artificial insemination in sheep - L’Insémination artificielle chez les ovins, 11-16 pp. In insémination artificielle ovine, Editions SEARLE – PARIS, 105p.
Colas G., 1980. Seasonal variations in semen quality in Ile-de-France rams. I. Study of cell morphology and mass motility - Variations saisonnières de la qualité du sperme chez les béliers Ile-de France. I. Etude de la morphologie cellulaire et de la motilité massale.. Reprod. Nutr. Dev., 20 (6): 1789-1799.
Colas G., 1981. Seasonal variations in semen quality in rams from Ile de France. II. Fertility in relation to the qualitative criteria observed in vitro - Variations saisonnières de la qualité du sperme chez les béliers île-de France. II. Fécondance relation avec les critères qualitatifs observés in vitro. Reprod. Nutr. Dev., 21: 399-407.
Colas G., Persomic D., Courot M., Ortavent R., 1975. Influence of harvesting rhythm on sperm production in young Romanov rams - Influence du rythme de la récolte sur la production des spermatozoïdes chez les jeunes béliers Romanov. Ann. Zootech., 24 (2): 189-198.
Contreras-Correa, Z. E., Messman, R. D., Swanson, R. M., & Lemley, C. O. (2023). Melatonin in Health and Disease: A Perspective for Livestock Production. Biomolecules, 13(3), 490.
Cosso, G, Mura, MC, Pulinas, L, Curone, G, Vigo, D, Carcangiu, V, et al. Effects of melatonin treatment on milk traits, reproductive performance and immune response in Sarda dairy sheep. Italian J Anim Sci. (2021) 20:632–9. doi: 10.1080/1828051X.2021.1904796
Doolen S, Krause DN, Dubocovich ML & Duckles SP 1998 Melatonin mediates two distinct responses in vascular smooth muscle. European Journal of Pharmacology 345 67–69. (doi:10.1016/S0014-2999(98)00064-8)
Dubocovich ML, Rivera-Bermudez MA, Gerdin MJ & Masana MI 2003 Molecular pharmacology, regulation, and function of mammalian melatonin receptors. Frontiers in Bioscience 8 d1093– d1108. (doi:10.2741/1089)
Dubocovich, M. L. (2007). Melatonin receptors: role on sleep and circadian rhythm regulation. Sleep medicine, 8, 34-42.
El-Far, M., Essam, A., Fardous, F., Abd El-Azim, A. O., Yahia, S., & El-Sherbiny, I. M. (2023). Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy.
Esquifino, A.I.; Pandi-Perumal, S.; Cardinali, D.P. Circadian organization of the immune response: A role for melatonin. Clin. Appl. Immunol. Rev. 2004, 4, 423–433.
Cipolla-Neto, J., & Amaral, F. G. D. (2018). Melatonin as a hormone: new physiological and clinical insights. Endocrine Reviews, 39(6), 990-1028.
Coelho, L. A., Silva, L. A., Reway, A. P., Buonfiglio, D. D. C., Andrade-Silva, J., Gomes, P. R. L., & Cipolla-Neto, J. (2023). Seasonal Variation of Melatonin Concentration and mRNA Expression of Melatonin-Related Genes in Developing Ovarian Follicles of Mares Kept under Natural Photoperiods in the Southern Hemisphere. Animals, 13(6), 1063.
Colas G., 1976. Artificial insemination in sheep - L’Insémination artificielle chez les ovins, 11-16 pp. In insémination artificielle ovine, Editions SEARLE – PARIS, 105p.
Colas G., 1980. Seasonal variations in semen quality in Ile-de-France rams. I. Study of cell morphology and mass motility - Variations saisonnières de la qualité du sperme chez les béliers Ile-de France. I. Etude de la morphologie cellulaire et de la motilité massale.. Reprod. Nutr. Dev., 20 (6): 1789-1799.
Colas G., 1981. Seasonal variations in semen quality in rams from Ile de France. II. Fertility in relation to the qualitative criteria observed in vitro - Variations saisonnières de la qualité du sperme chez les béliers île-de France. II. Fécondance relation avec les critères qualitatifs observés in vitro. Reprod. Nutr. Dev., 21: 399-407.
Colas G., Persomic D., Courot M., Ortavent R., 1975. Influence of harvesting rhythm on sperm production in young Romanov rams - Influence du rythme de la récolte sur la production des spermatozoïdes chez les jeunes béliers Romanov. Ann. Zootech., 24 (2): 189-198.
Contreras-Correa, Z. E., Messman, R. D., Swanson, R. M., & Lemley, C. O. (2023). Melatonin in Health and Disease: A Perspective for Livestock Production. Biomolecules, 13(3), 490.
Cosso, G, Mura, MC, Pulinas, L, Curone, G, Vigo, D, Carcangiu, V, et al. Effects of melatonin treatment on milk traits, reproductive performance and immune response in Sarda dairy sheep. Italian J Anim Sci. (2021) 20:632–9. doi: 10.1080/1828051X.2021.1904796
Doolen S, Krause DN, Dubocovich ML & Duckles SP 1998 Melatonin mediates two distinct responses in vascular smooth muscle. European Journal of Pharmacology 345 67–69. (doi:10.1016/S0014-2999(98)00064-8)
Dubocovich ML, Rivera-Bermudez MA, Gerdin MJ & Masana MI 2003 Molecular pharmacology, regulation, and function of mammalian melatonin receptors. Frontiers in Bioscience 8 d1093– d1108. (doi:10.2741/1089)
Dubocovich, M. L. (2007). Melatonin receptors: role on sleep and circadian rhythm regulation. Sleep medicine, 8, 34-42.
El-Far, M., Essam, A., Fardous, F., Abd El-Azim, A. O., Yahia, S., & El-Sherbiny, I. M. (2023). Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy.
Esquifino, A.I.; Pandi-Perumal, S.; Cardinali, D.P. Circadian organization of the immune response: A role for melatonin. Clin. Appl. Immunol. Rev. 2004, 4, 423–433.
Esteban-Zubero, E., López-Pingarrón, L., Ramírez, J. M., Reyes-Gonzales, M. C., Azúa-Romeo, F. J., Soria-Aznar, M., ... & García, J. J. (2023). Melatonin Preserves Fluidity in Cell and Mitochondrial
Membranes against Hepatic Ischemia–Reperfusion. Biomedicines, 11(7), 1940.
Fathi, M., Saeedyan, S., & Kaoosi, M. (2023). Effect of melatonin on oxidative stress, inflammation cytokines, biochemical parameters and growth performance in broiler chicken under induced stress by dexamethasone. Acta Agriculturae Scandinavica, Section A—Animal Science, 1-9.
Fischer T W, Elsner P. Melatonin: a hormone, drug or cosmeceutical. In: P Elsner, H I Maibacheds. Cosmeceuticals and Active Cosmetics, Vol. 1. Boca Raton: Taylor & Francis, 2005: 413–419.
Fischer T W, Elsner P. The antioxidative potential of melatonin in the skin. Curr Probl Dermatol 2001: 29: 165–174.
Fischer T W, Greif C, Fluhr J W, Wigger-Alberti W, Elsner P. Percutaneous penetration of topically applied melatonin in a cream and an alcoholic solution. Skin Pharmacol Physiol 2004: 17: 190– 194.
Fischer T W, Sweatman T W, Semak I, Sayre R M, Wortsman J, Slominski A. Constitutive and UV- induced melatonin metabolism in keratinocytes and cell-free systems. FASEB J 2006: 20: 1564–1566.
Fourtillan, J. B. (2002). Role of melatonin in the induction and maintenance of sleep. Dialogues in Clinical Neuroscience, 4(4), 395-401.
Furuyama, W., Enomoto, M., Mossaad, E., Kawai, S., Mikoshiba, K., & Kawazu, S. I. (2014). An interplay between 2 signaling pathways: Melatonin-cAMP and IP3–Ca2+ signaling pathways control intraerythrocytic development of the malaria parasite Plasmodium falciparum. Biochemical and biophysical research communications, 446(1), 125-131.
Galano, A.; Tan, D.X.; Reiter, R.J. On the Free Radical Scavenging Activities of Melatonin’s Metabolites, AFMK and AMK. J. Pineal Res. 2013, 54, 245–257.
Garcia‐Ispierto, I., Abdelfatah, A., & López‐Gatius, F. (2013). Melatonin treatment at dry‐off improves reproductive performance postpartum in high‐producing dairy cows under heat stress conditions. Reproduction in Domestic Animals, 48(4), 577-583.
Geary GG, Duckles SP & Krause DN 1998 Effect of melatonin in the rat tail artery: role of K+ channels and endothelial factors. British Journal of Pharmacology 123 1533–1540. (doi:10.1038/sj. bj.0701761)
Golpasandhagh, L., Samie, N., Sabiza, S., & Rezaie, A. (2023). Histopathological evaluation of the effect of melatonin gel on bone regeneration in rat model. Journal of Indian Society of Periodontology, 27(4), 368-373.
HAFEZ, Elsayed Saad Eldin; HAFEZ, B. (ed.). Reproduction in farm animals. John Wiley & Sons, 2013 Hajam, Y. A., & Rai, S. (2019). Melatonin and insulin modulate the cellular biochemistry, histoarchitecture, and receptor expression during hepatic injury in diabetic rats. Life
sciences, 239, 117046.
Hardeland, R. (2010). Melatonin metabolism in the central nervous system. Current neuropharmacology, 8(3), 168-181.
Membranes against Hepatic Ischemia–Reperfusion. Biomedicines, 11(7), 1940.
Fathi, M., Saeedyan, S., & Kaoosi, M. (2023). Effect of melatonin on oxidative stress, inflammation cytokines, biochemical parameters and growth performance in broiler chicken under induced stress by dexamethasone. Acta Agriculturae Scandinavica, Section A—Animal Science, 1-9.
Fischer T W, Elsner P. Melatonin: a hormone, drug or cosmeceutical. In: P Elsner, H I Maibacheds. Cosmeceuticals and Active Cosmetics, Vol. 1. Boca Raton: Taylor & Francis, 2005: 413–419.
Fischer T W, Elsner P. The antioxidative potential of melatonin in the skin. Curr Probl Dermatol 2001: 29: 165–174.
Fischer T W, Greif C, Fluhr J W, Wigger-Alberti W, Elsner P. Percutaneous penetration of topically applied melatonin in a cream and an alcoholic solution. Skin Pharmacol Physiol 2004: 17: 190– 194.
Fischer T W, Sweatman T W, Semak I, Sayre R M, Wortsman J, Slominski A. Constitutive and UV- induced melatonin metabolism in keratinocytes and cell-free systems. FASEB J 2006: 20: 1564–1566.
Fourtillan, J. B. (2002). Role of melatonin in the induction and maintenance of sleep. Dialogues in Clinical Neuroscience, 4(4), 395-401.
Furuyama, W., Enomoto, M., Mossaad, E., Kawai, S., Mikoshiba, K., & Kawazu, S. I. (2014). An interplay between 2 signaling pathways: Melatonin-cAMP and IP3–Ca2+ signaling pathways control intraerythrocytic development of the malaria parasite Plasmodium falciparum. Biochemical and biophysical research communications, 446(1), 125-131.
Galano, A.; Tan, D.X.; Reiter, R.J. On the Free Radical Scavenging Activities of Melatonin’s Metabolites, AFMK and AMK. J. Pineal Res. 2013, 54, 245–257.
Garcia‐Ispierto, I., Abdelfatah, A., & López‐Gatius, F. (2013). Melatonin treatment at dry‐off improves reproductive performance postpartum in high‐producing dairy cows under heat stress conditions. Reproduction in Domestic Animals, 48(4), 577-583.
Geary GG, Duckles SP & Krause DN 1998 Effect of melatonin in the rat tail artery: role of K+ channels and endothelial factors. British Journal of Pharmacology 123 1533–1540. (doi:10.1038/sj. bj.0701761)
Golpasandhagh, L., Samie, N., Sabiza, S., & Rezaie, A. (2023). Histopathological evaluation of the effect of melatonin gel on bone regeneration in rat model. Journal of Indian Society of Periodontology, 27(4), 368-373.
HAFEZ, Elsayed Saad Eldin; HAFEZ, B. (ed.). Reproduction in farm animals. John Wiley & Sons, 2013 Hajam, Y. A., & Rai, S. (2019). Melatonin and insulin modulate the cellular biochemistry, histoarchitecture, and receptor expression during hepatic injury in diabetic rats. Life
sciences, 239, 117046.
Hardeland, R. (2010). Melatonin metabolism in the central nervous system. Current neuropharmacology, 8(3), 168-181.
Hardeland, R., & Fuhrberg, B. (1996). Ubiquitous melatonin— Presence and effects in unicells, plants, and animals. Trends Comp. Biochem. Physiol., 2, 25–45.
Hardeland, R., & Poeggeler, B. (2003). Non-vertebrate melatonin. J. Pineal Res., 34, 233–241.
Hirata, F., Hayaishi, O., Tokuyama, T., & Senoh, S. (1974). In vitro and in vivo formation of two new metabolites of melatonin. J. Biol. Chem., 249, 1311–1313.
Horodincu, L., & Solcan, C. (2023). Influence of Different Light Spectra on Melatonin Synthesis by the Pineal Gland and Influence on the Immune System in Chickens. Animals, 13(13), 2095.
Hu, X., Li, J., Wang, X., Liu, H., Wang, T., Lin, Z., & Xiong, N. (2023). Neuroprotective Effect of Melatonin on Sleep Disorders Associated with Parkinson’s Disease. Antioxidants, 12(2), 396.
J Reiter, R., Tan, D. X., Rosales-Corral, S., & C Manchester, L. (2013). The universal nature, unequal distribution, and antioxidant functions of melatonin and its derivatives. Mini reviews in medicinal chemistry, 13(3), 373-384.
Jung, B., & Ahmad, N. (2006). Melatonin in cancer management: progress and promise. Cancer Research, 66(20), 9789-9793.
Karasek M. Ultrastructure of the mammalian pineal gland: its comparative and functional aspects. Pineal Res Rev 1983; 1: 1-48.
King TS, Steinlechner S. Pineal indolalkylamine synthesis and metabolism: kinetic considerations. Pineal Res Rev 1985; 3: 69-114.
Klein DC, Coon SL, Roseboom PH, et al. The melatonin rhythmegenerating enzyme: molecular regulation of serotonin Nacetyltransferase in the pineal gland.
Koyuncu M., Kara Uzun S., Ozis S. And Duru S., 2005. Development of testicular dimensions and size, and their relationship to age and body weight in growing Kivircik (Western Thrace) ram lambs. Czech Journal of Animal Science, 50 (6), 243–248.
Kubatka, P., Zubor, P., Busselberg, D., Kwon, T. K., Adamek, M., Petrovic, D., ....& Kruzliak, P. (2018).
Melatonin and breast cancer: Evidences from preclinical and human studies. Critical reviews in oncology/hematology, 122, 133-143.
Lech, J. C., Halma, M. T., Obajuluwa, A. O., Baker, M., & Hamblin, M. R. (2023). Fiat Lux: Light and Pedagogy for the 21st Century. Annals of Neurosciences, 09727531221136646.
Lerner AB, Case JD, Takahashi Y, et al. Isolation of melatonin: the pineal gland factor that lightens melanocytes. J Am Chem Soc 1958;80:2587e9.Lerner, A.B.; Case, J.D.; Takahashi, Y.; Lee, T.H.; Mori, W. Isolation of melatonin, the pineal gland factor that lightens melanocytes1 J. Am.
Chem. Soc. 1958, 80, 2587.
Li X, Zhang L, Ahammed GJ, Li ZX, Wei JP, Shen C, et al. Stimulation in primary and secondary metabolism by elevated carbon dioxide alters green tea quality in Camellia sinensis L. Sci Rep. (2017) 7:7937. doi: 10.1038/s41598-017-08465-1
Li, Z., Zhang, K., Zhou, Y., Zhao, J., Wang, J., & Lu, W. (2023). Role of Melatonin in Bovine Reproductive Biotechnology. Molecules, 28(13), 4940.
Liu J, Huang F, He HW. Melatonin effects on hard tissues:Bone and tooth. Int J Mol Sci 2013;14:10063– 74.
López-Valverde N, Pardal-Peláez B, López-Valverde A, Ramírez JM. Role of melatonin in bone remodeling around titanium dental implants:Meta-analysis. Coatings 2021;11:271.
Hardeland, R., & Poeggeler, B. (2003). Non-vertebrate melatonin. J. Pineal Res., 34, 233–241.
Hirata, F., Hayaishi, O., Tokuyama, T., & Senoh, S. (1974). In vitro and in vivo formation of two new metabolites of melatonin. J. Biol. Chem., 249, 1311–1313.
Horodincu, L., & Solcan, C. (2023). Influence of Different Light Spectra on Melatonin Synthesis by the Pineal Gland and Influence on the Immune System in Chickens. Animals, 13(13), 2095.
Hu, X., Li, J., Wang, X., Liu, H., Wang, T., Lin, Z., & Xiong, N. (2023). Neuroprotective Effect of Melatonin on Sleep Disorders Associated with Parkinson’s Disease. Antioxidants, 12(2), 396.
J Reiter, R., Tan, D. X., Rosales-Corral, S., & C Manchester, L. (2013). The universal nature, unequal distribution, and antioxidant functions of melatonin and its derivatives. Mini reviews in medicinal chemistry, 13(3), 373-384.
Jung, B., & Ahmad, N. (2006). Melatonin in cancer management: progress and promise. Cancer Research, 66(20), 9789-9793.
Karasek M. Ultrastructure of the mammalian pineal gland: its comparative and functional aspects. Pineal Res Rev 1983; 1: 1-48.
King TS, Steinlechner S. Pineal indolalkylamine synthesis and metabolism: kinetic considerations. Pineal Res Rev 1985; 3: 69-114.
Klein DC, Coon SL, Roseboom PH, et al. The melatonin rhythmegenerating enzyme: molecular regulation of serotonin Nacetyltransferase in the pineal gland.
Koyuncu M., Kara Uzun S., Ozis S. And Duru S., 2005. Development of testicular dimensions and size, and their relationship to age and body weight in growing Kivircik (Western Thrace) ram lambs. Czech Journal of Animal Science, 50 (6), 243–248.
Kubatka, P., Zubor, P., Busselberg, D., Kwon, T. K., Adamek, M., Petrovic, D., ....& Kruzliak, P. (2018).
Melatonin and breast cancer: Evidences from preclinical and human studies. Critical reviews in oncology/hematology, 122, 133-143.
Lech, J. C., Halma, M. T., Obajuluwa, A. O., Baker, M., & Hamblin, M. R. (2023). Fiat Lux: Light and Pedagogy for the 21st Century. Annals of Neurosciences, 09727531221136646.
Lerner AB, Case JD, Takahashi Y, et al. Isolation of melatonin: the pineal gland factor that lightens melanocytes. J Am Chem Soc 1958;80:2587e9.Lerner, A.B.; Case, J.D.; Takahashi, Y.; Lee, T.H.; Mori, W. Isolation of melatonin, the pineal gland factor that lightens melanocytes1 J. Am.
Chem. Soc. 1958, 80, 2587.
Li X, Zhang L, Ahammed GJ, Li ZX, Wei JP, Shen C, et al. Stimulation in primary and secondary metabolism by elevated carbon dioxide alters green tea quality in Camellia sinensis L. Sci Rep. (2017) 7:7937. doi: 10.1038/s41598-017-08465-1
Li, Z., Zhang, K., Zhou, Y., Zhao, J., Wang, J., & Lu, W. (2023). Role of Melatonin in Bovine Reproductive Biotechnology. Molecules, 28(13), 4940.
Liu J, Huang F, He HW. Melatonin effects on hard tissues:Bone and tooth. Int J Mol Sci 2013;14:10063– 74.
López-Valverde N, Pardal-Peláez B, López-Valverde A, Ramírez JM. Role of melatonin in bone remodeling around titanium dental implants:Meta-analysis. Coatings 2021;11:271.
Luchetti, F., Carloni, S., Nasoni, M. G., Reiter, R. J., & Balduini, W. (2023). Melatonin, tunneling nanotubes, mesenchymal cells, and tissue regeneration. Neural Regeneration Research, 18(4), 760.
Ma N, Guo P, Zhang J, He T, Kim SW, Zhang G, et al. Nutrients mediate intestinal bacteria-mucosal immune crosstalk. Front Immunol. (2018) 9:5. doi: 10.3389/fimmu.2018.00005
Ma N, Zhang J, Reiter RJ, Ma X. Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: a therapeutic target to reduce intestinal inflammation. Med Res Rev. (2020) 40:606–32. doi: 10.1002/med.21628
Mallaupoma, L. R. C., Dias, B. K. D. M., Singh, M. K., Honorio, R. I., Nakabashi, M., Kisukuri, C. D. M.,
... & Garcia, C. R. (2022). Decoding the role of melatonin structure on Plasmodium falciparum human malaria parasites synchronization using 2-sulfenylindoles derivatives. Biomolecules, 12(5), 638.
Mallaupoma, L. R. C., Dias, B. K. D. M., Singh, M. K., Honorio, R. I., Nakabashi, M., Kisukuri, C. D. M.,
... & Garcia, C. R. (2022). Decoding the role of melatonin structure on Plasmodium falciparum human malaria parasites synchronization using 2-sulfenylindoles derivatives. Biomolecules, 12(5), 638.
Malpaux, B.; Viguié, C.; Skinner, D.; Thiéry, J.; Pelletier, J.; Chemineau, P. Seasonal breeding in sheep: Mechanism of action of melatonin. Anim. Reprod. Sci. 1996, 42, 109–117.
Maronde E, Saade A, Ackermann K, et al. Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal gland. J Pineal Res 2011; 51: 145-155.
McArthur, A.J., Hunt, A.E., Gillette, M.U., 1997. Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn. Endocrinology 138, 627–634
McCord CP, Allen FP. Evidence associating pineal gland function with alterations in pigmentation. J Exp Zool 1917;23: 207e24.
Nachiappan, K. R., Sadasivam, B., Najmi, A., Chandrahasan, K., & Chandrahasan, K. (2023). Evaluation of the Anxiolytic Effect of Ramelteon in Various Rat Models of Anxiety. Cureus, 15(5).
Najafi M, Shirazi A, Motevaseli E, Rezaeyan AH, Salajegheh A, Rezapoor S. Melatonin as an anti- inflammatory agent in radiotherapy. Inflammopharmacology 2017;25:403–13.
Nguyen, B. T., Lin, C. Y., Chang, T. K., Fong, Y. C., Thadevoos, L. A., Lai, C. Y., .... & Tang, C. H. (2023).
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression. Journal of Pineal Research, 75(1), e12872.
O'Keeffe S, Beynon A, Davies J, Moynagh PN, Coogan A. NF-κB signalling is involved in immune- modulation, but not basal functioning, of the mouse suprachiasmatic circadian clock. Eur J Neurosci. (2017) 45:1111–23. doi 10.1111/ejn.13553
Pandi-Perumal, S. R., Trakht, I., Srinivasan, V., Spence, D. W., Maestroni, G. J., Zisapel, N., & Cardinali, D. P. (2008). Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Progress in neurobiology, 85(3), 335-353.
Ma N, Guo P, Zhang J, He T, Kim SW, Zhang G, et al. Nutrients mediate intestinal bacteria-mucosal immune crosstalk. Front Immunol. (2018) 9:5. doi: 10.3389/fimmu.2018.00005
Ma N, Zhang J, Reiter RJ, Ma X. Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: a therapeutic target to reduce intestinal inflammation. Med Res Rev. (2020) 40:606–32. doi: 10.1002/med.21628
Mallaupoma, L. R. C., Dias, B. K. D. M., Singh, M. K., Honorio, R. I., Nakabashi, M., Kisukuri, C. D. M.,
... & Garcia, C. R. (2022). Decoding the role of melatonin structure on Plasmodium falciparum human malaria parasites synchronization using 2-sulfenylindoles derivatives. Biomolecules, 12(5), 638.
Mallaupoma, L. R. C., Dias, B. K. D. M., Singh, M. K., Honorio, R. I., Nakabashi, M., Kisukuri, C. D. M.,
... & Garcia, C. R. (2022). Decoding the role of melatonin structure on Plasmodium falciparum human malaria parasites synchronization using 2-sulfenylindoles derivatives. Biomolecules, 12(5), 638.
Malpaux, B.; Viguié, C.; Skinner, D.; Thiéry, J.; Pelletier, J.; Chemineau, P. Seasonal breeding in sheep: Mechanism of action of melatonin. Anim. Reprod. Sci. 1996, 42, 109–117.
Maronde E, Saade A, Ackermann K, et al. Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal gland. J Pineal Res 2011; 51: 145-155.
McArthur, A.J., Hunt, A.E., Gillette, M.U., 1997. Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn. Endocrinology 138, 627–634
McCord CP, Allen FP. Evidence associating pineal gland function with alterations in pigmentation. J Exp Zool 1917;23: 207e24.
Nachiappan, K. R., Sadasivam, B., Najmi, A., Chandrahasan, K., & Chandrahasan, K. (2023). Evaluation of the Anxiolytic Effect of Ramelteon in Various Rat Models of Anxiety. Cureus, 15(5).
Najafi M, Shirazi A, Motevaseli E, Rezaeyan AH, Salajegheh A, Rezapoor S. Melatonin as an anti- inflammatory agent in radiotherapy. Inflammopharmacology 2017;25:403–13.
Nguyen, B. T., Lin, C. Y., Chang, T. K., Fong, Y. C., Thadevoos, L. A., Lai, C. Y., .... & Tang, C. H. (2023).
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression. Journal of Pineal Research, 75(1), e12872.
O'Keeffe S, Beynon A, Davies J, Moynagh PN, Coogan A. NF-κB signalling is involved in immune- modulation, but not basal functioning, of the mouse suprachiasmatic circadian clock. Eur J Neurosci. (2017) 45:1111–23. doi 10.1111/ejn.13553
Pandi-Perumal, S. R., Trakht, I., Srinivasan, V., Spence, D. W., Maestroni, G. J., Zisapel, N., & Cardinali, D. P. (2008). Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Progress in neurobiology, 85(3), 335-353.
Papis K, Poleszczuk O, Wenta-Muchalska E, Modlinski JA, 2007: Melatonin effect on bovine embryo development in vitro in relation to oxygen concentration. J Pineal Res 43, 321–326.
Patel, R., Parmar, N., Palit, S. P., Rathwa, N., Ramachandran, A. V., & Begum, R. (2022). Diabetes mellitus and melatonin: Where are we? Biochimie.
Paulis L & Simko F 2007 Blood pressure modulation and cardiovascular protection by melatonin: Potential mechanisms behind. Physiological Research 56 671–684.
Paulis, L., & Šimko, F. (2007). Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind. Physiological research, 56(6).
Paulose JK, Cassone VM. The melatonin-sensitive circadian clock of the enteric bacterium Enterobacter aerogenes. Gut Microbes. (2016) 7:424–7. doi: 10.1080/19490976.2016.1208892 Paulose JK, Wright JM, Patel AG, Cassone VM. Human gut bacteria are sensitive to melatonin and express endogenous circadian rhythmicity. PLoS One. (2016) 11:e0146643. doi:
10.1371/journal.pone.0146643
Perreau-Lenz S, Pevet P, Buijs RM, et al. The biological clock: the bodyguard of temporal homeostasis. Chronobiol Int 2004;21:1e25
Peschke, E., Bähr, I., & Mühlbauer, E. (2013). Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon. International journal of molecular sciences, 14(4), 6981-7015.
Pfeffer, M., Korf, H. W., & Wicht, H. (2018). Synchronizing effects of melatonin on diurnal and circadian rhythms. General and comparative endocrinology, 258, 215-221.
Planski, V, Yotov, S, Parvanov, P, Karadaev, M, Ilieva, Y, Hristov, K, et al. Influence of melatonin treatment on puberty onset in buffalo heifers from Bulgarian Murrah breed. Trad Mod Vet Med. (2017) 2:56–60. Available
RAHAWY, M. A. Variations in the coding of melatonin receptor gene MTNR1A of Iraqi sheep breed: Rahawy, MA 1; AlTimimi, IH 2, Najwa, Sh. Ahmad3 and Ani A. A4. The Iraqi Journal of Veterinary Medicine, 2017, 41.1: 98- 103. Rahman MA, Azuma Y, Fukunaga H, Murakami T, Sugi K, Fukushi H, et al. Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia. J Antimicrob Chemother. (2005) 56:861–8. doi: 10.1093/jac/dki331
Regodón, S.; Ramos, A.; Míguez, M.P.; Carrillo-Vico, A.; Rosado, J.A.; Jardín, I. Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep. BMC Veter. Res. 2012, 8, 84.
Reiter RJ, Tan DX & Korkmaz A 2009 The circadian melatonin rhythm and its modulation: possible impact on hypertension. Journal of Hypertension 27 (Suppl 6) S17–S20. (doi:10.1097/01.hjh.0000358832.41181.bf)
Reiter, R. J. (1998). Oxidative damage in the central nervous system: protection by melatonin. Progress in neurobiology, 56(3), 359-384.
Reiter, R. J., & Tan, D. X. (2003). Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovascular research, 58(1), 10-19.
Patel, R., Parmar, N., Palit, S. P., Rathwa, N., Ramachandran, A. V., & Begum, R. (2022). Diabetes mellitus and melatonin: Where are we? Biochimie.
Paulis L & Simko F 2007 Blood pressure modulation and cardiovascular protection by melatonin: Potential mechanisms behind. Physiological Research 56 671–684.
Paulis, L., & Šimko, F. (2007). Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind. Physiological research, 56(6).
Paulose JK, Cassone VM. The melatonin-sensitive circadian clock of the enteric bacterium Enterobacter aerogenes. Gut Microbes. (2016) 7:424–7. doi: 10.1080/19490976.2016.1208892 Paulose JK, Wright JM, Patel AG, Cassone VM. Human gut bacteria are sensitive to melatonin and express endogenous circadian rhythmicity. PLoS One. (2016) 11:e0146643. doi:
10.1371/journal.pone.0146643
Perreau-Lenz S, Pevet P, Buijs RM, et al. The biological clock: the bodyguard of temporal homeostasis. Chronobiol Int 2004;21:1e25
Peschke, E., Bähr, I., & Mühlbauer, E. (2013). Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon. International journal of molecular sciences, 14(4), 6981-7015.
Pfeffer, M., Korf, H. W., & Wicht, H. (2018). Synchronizing effects of melatonin on diurnal and circadian rhythms. General and comparative endocrinology, 258, 215-221.
Planski, V, Yotov, S, Parvanov, P, Karadaev, M, Ilieva, Y, Hristov, K, et al. Influence of melatonin treatment on puberty onset in buffalo heifers from Bulgarian Murrah breed. Trad Mod Vet Med. (2017) 2:56–60. Available
RAHAWY, M. A. Variations in the coding of melatonin receptor gene MTNR1A of Iraqi sheep breed: Rahawy, MA 1; AlTimimi, IH 2, Najwa, Sh. Ahmad3 and Ani A. A4. The Iraqi Journal of Veterinary Medicine, 2017, 41.1: 98- 103. Rahman MA, Azuma Y, Fukunaga H, Murakami T, Sugi K, Fukushi H, et al. Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia. J Antimicrob Chemother. (2005) 56:861–8. doi: 10.1093/jac/dki331
Regodón, S.; Ramos, A.; Míguez, M.P.; Carrillo-Vico, A.; Rosado, J.A.; Jardín, I. Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep. BMC Veter. Res. 2012, 8, 84.
Reiter RJ, Tan DX & Korkmaz A 2009 The circadian melatonin rhythm and its modulation: possible impact on hypertension. Journal of Hypertension 27 (Suppl 6) S17–S20. (doi:10.1097/01.hjh.0000358832.41181.bf)
Reiter, R. J. (1998). Oxidative damage in the central nervous system: protection by melatonin. Progress in neurobiology, 56(3), 359-384.
Reiter, R. J., & Tan, D. X. (2003). Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovascular research, 58(1), 10-19.
Reiter, R. J., Sharma, R., Romero, A., Manucha, W., Tan, D. X., Zuccari, D. A. P. D. C., & Chuffa, L. G. D. A. (2023). Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue. Antioxidants, 12(3), 695.
Reiter, R.J.; Hester, R.J. Interrelationships of the Pineal Gland, the Superior Cervical Ganglia and the Photoperiod in the Regulation of the Endocrine Systems of Hamsters. Endocrinology 1966, 79, 1168–1170.
Reppert, S.M., Godson, C., Mahle, C.D., Weaver, D.R., Slaugenhaupt, S.A., Gusella, J.F., 1995. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc. Natl. Acad. Sci. U.S.A. 92, 8734–8738.
Reppert, S.M., Weaver, D.R., Ebisawa, T., 1994. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 13, 1177–1185 Ronayne, E.; Jordan, B.; Quirke, J.; Roche, J. The effect of frequency of administration of melatonin on the time of onset of the breeding season in anoestrous ewes. Anim. Reprod. Sci. 1989, 18, 13–
24.
ROSA, H. J. D.; SILVA, C. C.; BRYANT, M. J. The effect of melatonin treatment in rams on seasonal variation of testicular size and semen production parameters. Small ruminant research, 2012, 102.2-3: 197-201.
Ruiz-Cano, D., Sánchez-Carrasco, G., El-Mihyaoui, A., & B. Arnao, M. (2022). Essential oils and melatonin as functional ingredients in dogs. Animals, 12(16), 2089.
Salomó-Coll O, de Maté-Sánchez JE, Ramírez-Fernandez MP, Hernández-Alfaro F, Gargallo-Albiol J, Calvo-Guirado JL. Osseoinductive elements around immediate implants for better osteointegration:A pilot study in foxhound dogs. Clin Oral Implants Res 2018;29:1061–9.
SARLÓS, P., et al. Seasonal changes of scrotal circumference, blood plasma testosterone concentration and semen characteristics in Racka rams. Small Ruminant Research, 2013, 111.1-3: 90- 95.
Schallreuter K U, Bahadoran P, Picardo M , et al. Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Dermatol 2008: 17: 139–140
Scheer FAJL, Ter Horst GJ, Van der Vliet J, Buijs RM. Physiological and anatomic evidence for regulation of the heart by the suprachiasmatic nucleus in rats. Am J Physiol. 2001; 280: H1391– H1399.
Scheer FAJL, van Doornen LJP, Buijs RM. Light and diurnal cycle affect human heart rate: a possible role for the circadian pacemaker. J Biol Rhythms. 1999; 14: 202–212.
Scheer, F. A., Van Montfrans, G. A., van Someren, E. J., Mairuhu, G., & Buijs, R. M. (2004). Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension, 43(2), 192-197.
Simonneaux V, Ribeleyga C. Generation of the melatonin endocrine message in mamals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides and other pineal transmitters. Pharmacol Rev 2003;55: 325e95.
Slominski A, Tobin D J, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 2004: 84: 1155–1228.
Reiter, R.J.; Hester, R.J. Interrelationships of the Pineal Gland, the Superior Cervical Ganglia and the Photoperiod in the Regulation of the Endocrine Systems of Hamsters. Endocrinology 1966, 79, 1168–1170.
Reppert, S.M., Godson, C., Mahle, C.D., Weaver, D.R., Slaugenhaupt, S.A., Gusella, J.F., 1995. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc. Natl. Acad. Sci. U.S.A. 92, 8734–8738.
Reppert, S.M., Weaver, D.R., Ebisawa, T., 1994. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 13, 1177–1185 Ronayne, E.; Jordan, B.; Quirke, J.; Roche, J. The effect of frequency of administration of melatonin on the time of onset of the breeding season in anoestrous ewes. Anim. Reprod. Sci. 1989, 18, 13–
24.
ROSA, H. J. D.; SILVA, C. C.; BRYANT, M. J. The effect of melatonin treatment in rams on seasonal variation of testicular size and semen production parameters. Small ruminant research, 2012, 102.2-3: 197-201.
Ruiz-Cano, D., Sánchez-Carrasco, G., El-Mihyaoui, A., & B. Arnao, M. (2022). Essential oils and melatonin as functional ingredients in dogs. Animals, 12(16), 2089.
Salomó-Coll O, de Maté-Sánchez JE, Ramírez-Fernandez MP, Hernández-Alfaro F, Gargallo-Albiol J, Calvo-Guirado JL. Osseoinductive elements around immediate implants for better osteointegration:A pilot study in foxhound dogs. Clin Oral Implants Res 2018;29:1061–9.
SARLÓS, P., et al. Seasonal changes of scrotal circumference, blood plasma testosterone concentration and semen characteristics in Racka rams. Small Ruminant Research, 2013, 111.1-3: 90- 95.
Schallreuter K U, Bahadoran P, Picardo M , et al. Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Dermatol 2008: 17: 139–140
Scheer FAJL, Ter Horst GJ, Van der Vliet J, Buijs RM. Physiological and anatomic evidence for regulation of the heart by the suprachiasmatic nucleus in rats. Am J Physiol. 2001; 280: H1391– H1399.
Scheer FAJL, van Doornen LJP, Buijs RM. Light and diurnal cycle affect human heart rate: a possible role for the circadian pacemaker. J Biol Rhythms. 1999; 14: 202–212.
Scheer, F. A., Van Montfrans, G. A., van Someren, E. J., Mairuhu, G., & Buijs, R. M. (2004). Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension, 43(2), 192-197.
Simonneaux V, Ribeleyga C. Generation of the melatonin endocrine message in mamals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides and other pineal transmitters. Pharmacol Rev 2003;55: 325e95.
Slominski A, Tobin D J, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 2004: 84: 1155–1228.
Slominski A, Wortsman J, Plonka P M, Schallreuter K U, Paus R, Tobin D J. Hair follicle pigmentation. J Invest Dermatol 2005: 124: 13–21.
Sly DJ, Colvill L, McKinley MJ, Oldfield BJ. Identification of neural projections from the forebrain to the kidney, using the virus pseudorabies. J Autonom Nerv Syst. 1999; 77: 73–82. Srinivasan V, Mohamed M, Kato H. Melatonin in bacterial and viral infections with focus on sepsis: a review. Recent Pat Endocr Metab Immune Drug Discov. (2012) 6:30–9. doi: 10.2174/187221412799015317
Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008). Therapeutic actions of melatonin in cancer: possible mechanisms. Integrative cancer therapies, 7(3), 189- 203.
Suzen, S. (2018). Melatonin and its antiaging activity: new approaches and strategies for age-related disorders. Molecular Basis and Emerging Strategies for Anti-aging Interventions, 217-235.
Takada L, Junior AM, Mingoti GZ, Balieiro JC, Cipolla-Neto J, Coelho LA, 2012: Effect of melatonin on DNA damage of bovine cumulus cells during in vitro mat uration (IVM) and on in vitro embryo development. Res Vet Sci 92, 124–127.
Tamura H, Nakamura Y, Takiguchi S, Kashida S, Yamagata Y, Sugino N, Kato H, 1998: Pinealectomy of melatonin implantation does not affect prolactin surge or luteal function in pseudopregnant rats. Endocr J 45, 377–383.
Tamura H, Nakamura Y, Terron MP, Flores LJ, Manchester LC, Tan DX, Sugino N, Reiter RJ, 2008a: Melatonin and pregnancy in the human. Reprod Toxicol 25, 291–303.
Tamura H, Takayama H, Nakamura Y, Reiter RJ, Sugino N, 2008b: Fetal/placental regulation of maternal melatonin in rats. J Pineal Res 44, 335–340.
Tamura, H., Takasaki, A., Taketani, T., Tanabe, M., Kizuka, F., Lee, L., ..... & Sugino, N. (2013).
Melatonin is a free radical scavenger in the ovarian follicle. Endocrine journal, 60(1), 1-13.
Tan, D. X., Reiter, R. J., Zimmerman, S., & Hardeland, R. (2023). Melatonin: Both a messenger of darkness and a participant in the cellular actions of non-visible solar radiation of near infrared light. Biology, 12(1), 89.
Tariq M. M., Eyduran E., Bajwa M. A., Waheed A., Igbal F. And Javed Y., 2012. Prediction of body
weight from testicular and morphological characteristics in indigenous mengali sheep of Pakistan: Using factor analysis scores in multiple linear regression analysis. International Journal of Agriculture and Biology, 14, 590-594.
Tchekalarova, J., & Tzoneva, R. (2023). Oxidative Stress and Aging as Risk Factors for Alzheimer’s Disease and Parkinson’s Disease: The Role of the Antioxidant Melatonin. International Journal of Molecular Sciences, 24(3), 3022. Tekbas OF, Ogur R, Korkmaz A, Kilic A, Reiter RJ. Melatonin as an antibiotic: new insights into the actions of this ubiquitous molecule. J Pineal Res. (2008) 44:222–6. doi: 10.1111/j.1600- 079X.2007.00516.x
Tricoire H, Locatelli A, Chemineau P, Malpaux B. Melatonin enters the cerebrospinal fluid through the pineal recess. Endocrinology 2002; 143 84-90
Sly DJ, Colvill L, McKinley MJ, Oldfield BJ. Identification of neural projections from the forebrain to the kidney, using the virus pseudorabies. J Autonom Nerv Syst. 1999; 77: 73–82. Srinivasan V, Mohamed M, Kato H. Melatonin in bacterial and viral infections with focus on sepsis: a review. Recent Pat Endocr Metab Immune Drug Discov. (2012) 6:30–9. doi: 10.2174/187221412799015317
Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008). Therapeutic actions of melatonin in cancer: possible mechanisms. Integrative cancer therapies, 7(3), 189- 203.
Suzen, S. (2018). Melatonin and its antiaging activity: new approaches and strategies for age-related disorders. Molecular Basis and Emerging Strategies for Anti-aging Interventions, 217-235.
Takada L, Junior AM, Mingoti GZ, Balieiro JC, Cipolla-Neto J, Coelho LA, 2012: Effect of melatonin on DNA damage of bovine cumulus cells during in vitro mat uration (IVM) and on in vitro embryo development. Res Vet Sci 92, 124–127.
Tamura H, Nakamura Y, Takiguchi S, Kashida S, Yamagata Y, Sugino N, Kato H, 1998: Pinealectomy of melatonin implantation does not affect prolactin surge or luteal function in pseudopregnant rats. Endocr J 45, 377–383.
Tamura H, Nakamura Y, Terron MP, Flores LJ, Manchester LC, Tan DX, Sugino N, Reiter RJ, 2008a: Melatonin and pregnancy in the human. Reprod Toxicol 25, 291–303.
Tamura H, Takayama H, Nakamura Y, Reiter RJ, Sugino N, 2008b: Fetal/placental regulation of maternal melatonin in rats. J Pineal Res 44, 335–340.
Tamura, H., Takasaki, A., Taketani, T., Tanabe, M., Kizuka, F., Lee, L., ..... & Sugino, N. (2013).
Melatonin is a free radical scavenger in the ovarian follicle. Endocrine journal, 60(1), 1-13.
Tan, D. X., Reiter, R. J., Zimmerman, S., & Hardeland, R. (2023). Melatonin: Both a messenger of darkness and a participant in the cellular actions of non-visible solar radiation of near infrared light. Biology, 12(1), 89.
Tariq M. M., Eyduran E., Bajwa M. A., Waheed A., Igbal F. And Javed Y., 2012. Prediction of body
weight from testicular and morphological characteristics in indigenous mengali sheep of Pakistan: Using factor analysis scores in multiple linear regression analysis. International Journal of Agriculture and Biology, 14, 590-594.
Tchekalarova, J., & Tzoneva, R. (2023). Oxidative Stress and Aging as Risk Factors for Alzheimer’s Disease and Parkinson’s Disease: The Role of the Antioxidant Melatonin. International Journal of Molecular Sciences, 24(3), 3022. Tekbas OF, Ogur R, Korkmaz A, Kilic A, Reiter RJ. Melatonin as an antibiotic: new insights into the actions of this ubiquitous molecule. J Pineal Res. (2008) 44:222–6. doi: 10.1111/j.1600- 079X.2007.00516.x
Tricoire H, Locatelli A, Chemineau P, Malpaux B. Melatonin enters the cerebrospinal fluid through the pineal recess. Endocrinology 2002; 143 84-90
Üstündağ, H., Doğanay, S., Kalındemirtaş, F. D., Demir, Ö., Huyut, M. T., Kurt, N., ..... & Akbaba, Ö.
(2023). A new treatment approach: Melatonin and ascorbic acid synergy shields against sepsis- induced heart and kidney damage in male rats. Life Sciences, 329, 121875.
Vaughan GM, Pelham RW, Pang SF, et al. Nocturnal elevation of plasma melatonin and urinary 5-
hydroxyindoleacetic acid in young men: attempts at modification by brief changes in environmental lighting and sleep and by autonomic drugs. J Clin Endocrinol Metab 1976; 42: 752-764
Viswanathan M, Scalbert E, Delagrange P, Guardiola-Lemaître B & Saavedra JM 1997 Melatonin receptors mediate contraction of a rat cerebral artery. Neuroreport 8 ....3847–3849.
(doi:10.1097/00001756-199712220-00002)
von Gall, C., Stehle, J.H., Weaver, D.R., 2002. Mammalian melatonin receptors: molecular biology and
signal transduction. Cell Tissue Res. 309, 151–162.
Winiarska, K., Fraczyk, T., Malinska, D., Drozak, J., & Bryla, J. (2006). Melatonin attenuates diabetes‐ induced oxidative stress in rabbits. Journal of Pineal Research, 40(2), 168-176.
Witt-Enderby, P.A., Bennett, J., Jarzynka, M.J., Firestine, S., Melan, M.A., 2003. Melatonin receptors
and their regulation: biochemical and structural mechanisms. Life Sci. 72, 2183–2198.
Witt-Enderby, P.A., Jarzynka, M.J., Krawitt, B.J., Melan, M.A., 2004. Knock-down of RGS4 and beta
tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization. Life Sci. 75, 2703–2715.
Wu X, Qiao S, Wang W, Zhang Y, Shi J, Zhang X, et al. Melatonin prevents periimplantitis via suppression of TLR4/NF-kB. Acta Biomater 2021;134:325–36.
Wu, H, Yao, S, Wang, T, Wang, J, Ren, K, Yang, H, et al. Effects of melatonin on dairy herd improvement (DHI) of Holstein cow with mastitis. Endocrinology. (2020) 12:450–9. doi: 10.3390/molecules26040834
Xia, Y., Geng, N., Ren, J., Liao, C., Wang, M., Chen, S., .... & Peng, W. (2023). Regulation of endothelial
cells on the osteogenic ability of bone marrow mesenchymal stem cells in peri-implantitis. Tissue and Cell, 81, 102042.
Xia, Y., Geng, N., Ren, J., Liao, C., Wang, M., Chen, S., .... & Peng, W. (2023). Regulation of endothelial
cells on the osteogenic ability of bone marrow mesenchymal stem cells in peri- implantitis. Tissue and Cell, 81, 102042.
Yin J, Li Y, Han H, Ma J, Liu G, Wu X, et al. Administration of exogenous melatonin improves the diurnal rhythms of the gut microbiota in mice fed a high-fat diet. mSystem. (2020) 5:e00002–20. doi: 10.1128/mSystems.00002-20
Zhao, T., Zhang, H., Jin, C., Qiu, F., Wu, Y., & Shi, L. (2017). Melatonin mediates vasodilation through both direct and indirect activation of BKCa channels. Journal of Molecular Endocrinology, 59(3), 219-233.
Zhu D, Ma Y, Ding S, Jiang H, Fang J. Effects of melatonin on intestinal microbiota and oxidative stress in colitis mice. BioMed Res Int. (2018) 2018:2607679. doi 10.1155/2018/2607679
(2023). A new treatment approach: Melatonin and ascorbic acid synergy shields against sepsis- induced heart and kidney damage in male rats. Life Sciences, 329, 121875.
Vaughan GM, Pelham RW, Pang SF, et al. Nocturnal elevation of plasma melatonin and urinary 5-
hydroxyindoleacetic acid in young men: attempts at modification by brief changes in environmental lighting and sleep and by autonomic drugs. J Clin Endocrinol Metab 1976; 42: 752-764
Viswanathan M, Scalbert E, Delagrange P, Guardiola-Lemaître B & Saavedra JM 1997 Melatonin receptors mediate contraction of a rat cerebral artery. Neuroreport 8 ....3847–3849.
(doi:10.1097/00001756-199712220-00002)
von Gall, C., Stehle, J.H., Weaver, D.R., 2002. Mammalian melatonin receptors: molecular biology and
signal transduction. Cell Tissue Res. 309, 151–162.
Winiarska, K., Fraczyk, T., Malinska, D., Drozak, J., & Bryla, J. (2006). Melatonin attenuates diabetes‐ induced oxidative stress in rabbits. Journal of Pineal Research, 40(2), 168-176.
Witt-Enderby, P.A., Bennett, J., Jarzynka, M.J., Firestine, S., Melan, M.A., 2003. Melatonin receptors
and their regulation: biochemical and structural mechanisms. Life Sci. 72, 2183–2198.
Witt-Enderby, P.A., Jarzynka, M.J., Krawitt, B.J., Melan, M.A., 2004. Knock-down of RGS4 and beta
tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization. Life Sci. 75, 2703–2715.
Wu X, Qiao S, Wang W, Zhang Y, Shi J, Zhang X, et al. Melatonin prevents periimplantitis via suppression of TLR4/NF-kB. Acta Biomater 2021;134:325–36.
Wu, H, Yao, S, Wang, T, Wang, J, Ren, K, Yang, H, et al. Effects of melatonin on dairy herd improvement (DHI) of Holstein cow with mastitis. Endocrinology. (2020) 12:450–9. doi: 10.3390/molecules26040834
Xia, Y., Geng, N., Ren, J., Liao, C., Wang, M., Chen, S., .... & Peng, W. (2023). Regulation of endothelial
cells on the osteogenic ability of bone marrow mesenchymal stem cells in peri-implantitis. Tissue and Cell, 81, 102042.
Xia, Y., Geng, N., Ren, J., Liao, C., Wang, M., Chen, S., .... & Peng, W. (2023). Regulation of endothelial
cells on the osteogenic ability of bone marrow mesenchymal stem cells in peri- implantitis. Tissue and Cell, 81, 102042.
Yin J, Li Y, Han H, Ma J, Liu G, Wu X, et al. Administration of exogenous melatonin improves the diurnal rhythms of the gut microbiota in mice fed a high-fat diet. mSystem. (2020) 5:e00002–20. doi: 10.1128/mSystems.00002-20
Zhao, T., Zhang, H., Jin, C., Qiu, F., Wu, Y., & Shi, L. (2017). Melatonin mediates vasodilation through both direct and indirect activation of BKCa channels. Journal of Molecular Endocrinology, 59(3), 219-233.
Zhu D, Ma Y, Ding S, Jiang H, Fang J. Effects of melatonin on intestinal microbiota and oxidative stress in colitis mice. BioMed Res Int. (2018) 2018:2607679. doi 10.1155/2018/2607679
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30th March, 2024
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Jumnake AR, Patodkar VR, Gavali NE, Sardar VM. and Mehere PV. Advances in Melatonin Research – A Review. Chron Aquat Sci. 2024;1(10):152-174
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Advances in Melatonin Research – A Review
